NSC 112929
Sennoside A
CAS: 81-27-6
Molecular Formula: C42H38O20
NSC 112929 - Names and Identifiers
| Name | Sennoside A |
| Synonyms | SENNOSIDA NSC 112929 Sennoside A Sennoside A1 SENNOSIDE A(P) SENNOSIDE A(SH) Sennoside A std. Senna Leaf Extract [9,9'-Bianthracene]-2,2'-dicarboxylicacid,5,5'-bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-,(9R,9'R)- (9R,9'R)-5,5'-bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid (9R,9'S)-5,5'-bis(alpha-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid (9,9'-Bianthracene)-2,2'-dicarboxylic acid, 5,5'-bis(beta-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo-, (R*,R*)- 9-[2-carboxy-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracen-9-yl]-4-hydroxy-10-oxo-5-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-9H-anthracene-2-carboxylic acid |
| CAS | 81-27-6 |
| EINECS | 201-339-9 |
| InChI | InChI=1/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24+,25-,26+,31-,32-,35+,36-,37+,38+,41-,42-/m0/s1 |
| InChIKey | IPQVTOJGNYVQEO-KGFNBKMBSA-N |
NSC 112929 - Physico-chemical Properties
| Molecular Formula | C42H38O20 |
| Molar Mass | 862.74 |
| Density | 1.743±0.06 g/cm3(Predicted) |
| Melting Point | >191oC (dec.) |
| Boling Point | 1144.8±65.0 °C(Predicted) |
| Specific Rotation(α) | D20 -164° (c = 0.1 in 60% acetone); D20 -147° (c = 0.1 in 70% acetone); D20 -24° (c = 0.2 in 70% dio |
| Flash Point | 348.6°C |
| Solubility | Insoluble in water, benzene, ether, chloroform, slightly soluble in methanol, diglycoside alcohol-ether, acetone, dioxane, soluble in sodium bicarbonate aqueous solution. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Pale yellow crystal |
| Color | Yellow to Dark Yellow |
| BRN | 5723746 |
| pKa | 3.31±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.762 |
| MDL | MFCD00151527 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Senna, rhubarb. |
| In vitro study | Sennoside A, A stimulant laxative isolated from the rhizome of Rhubarb, has A laxative effect by regulating spontaneous movements of the colon. It slightly regulates bovine blood monoamine oxidase with an IC50 of 17 μm. |
| In vivo study | LD50: mice 5000 mg/kg (Gavage); Rats 5000 mg/kg (Gavage). |
NSC 112929 - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29173990 |
NSC 112929 - Reference
| Reference Show more | 1. Zhao Qian, Chen Yupeng, Cui Xusheng, etc. Determination of UPLC multi-index components and fingerprint of Rheum palmatum L. [J]. Journal of Pharmaceutical Analysis, 2018, 038(010):1697-1710. 2. Luo Shan, Huang Wang Chen, Liu Xie, Lu Yingying, Li Xieyuan, Tang Wenqiang. Establishment of fingerprint of water extract of Alisma orientalis based on UPLC [J]. Shaanxi Agricultural Sciences, 2021,67(01):49-52. 3. Zhang Mingming. Study on the construction of core collection and selection of superior germplasm of rhubarb [D]. Beijing University of Chinese Medicine, 2020. 4. Lu Jie, Wang Tingting, Liang Yi, an Yi, Wang Xinhong, Chen Ying. Analysis of chemical constituents of dachengqi decoction by UPLC-LTQ-Orbitrap-MS [J]. Chinese traditional medicines, 2020,42(12):3275-3280. 5. Li Yang et al. [IF = 7.514]. "Color-reflected chemical regulations of the scorched rhubarb (rhei Radix et rhizoma) revealed by the integration analysis of visible spectrophotometry, Fourier transform infrared spectroscopy and high performance liquid chromatography." Food 6. [IF = 3.361] Yanhui Zhao et al."Rapid characterization of the chemical constituents of Sanhua decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry."Rsc Adv. 2020 Jul;10(44):26109-26119 7. [IF=4.098] Le Yang et al."Two-dimensional correlation spectroscopy indicates the infrared spectral markers of the optimum scorching degree of rhubarb (Rhei Radix et Rhizoma) to enhance the anti-inflammatory activity."Spectrochim Acta A. 2022 Apr;270:120853 8. [IF=5.645] Huilan Yue et al."Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities."Ind Crop Prod. 2022 Apr;178:114595 |
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Tel: 18301782025
Email: 3008007409@qq.com
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QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sennoside A Visit Supplier Webpage Request for quotationCAS: 81-27-6
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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